Not just Holistic, but how to use E: All of the Above!

We made this blog because we did tons of research on success stories and research worldwide and used it on my dog with nasal cancer named Lucy. Oddly, my hobby is molecular biology. The treatment uses combination of health store supplements, some prescription meds, diet changes, and specific Ayurvedic and Chinese medicinal herbs. We just wanted her to have a better quality of life. We thought this combination of E: All the Above (except no radiation or chemo) would help that for sure, but it actually put her bleeding nasal cancer in remission!
Our approach to cancer is about treating the whole animals biologic system as natural as possible. But I do hate the word 'Holistic'. Sounds like hoo hoo. This is science based, research based data and results of using active herbal compounds that happen to be readily available and common. Some call it Nutriceuticals. Others may call it Orthomolecular cancer therapy. Or Cancer Immunotherapy.
WE FEEL DIVERSITY IN TREATMENT IS KEY:
-Kill the cancer cells
-Rid the cancer cells
-Remove the toxins it produces
-Make cancer cells become easier targets for the immune system
-Slow cancer cell reproduction
-Stimulate AND modulate the immune system
-Control secondary symptoms like bleeding, infection, inflammation, mucous, appetite, or pain for a better feeling animal.
-Working with your vet for exams and prescriptions that are sometimes needed when conditions are acute.
Just by using a multi-modal treatment approach that is as diverse in attack as possible. Both conventional and natural.
The body conditions that allowed it to develop in the first place must be corrected. If caught early enough, like with Lucy, this ongoing maintenance correctional treatment is all that was required at this point to achieve, so far, more than 10 TIMES the life expectancy (48 months so far) after diagnosis WITH remission. I did not use radiation or chemotherapy.
I hope this cancer research can help your dog.
Lucy's nasal cancer is still in remission!

Lucy

Lucy

August 17, 2015

AGARIKON MUSHROOMS FOR CANCER




Immune stimulant, anti-viral, and anti-bacterial.


ABOUT AGARIKON MUSHROOMS
Over 2,000 years ago, a famous Greek physician, Pedanius Dioscorides, used this polypore as a curative, most notably for consumption (tuberculosis). Containing Agaric Acid, Agarikon has been used over the centuries in numerous preparations and by many indigenous cultures. These unique mushrooms only grow in the remaining old growth forests of Europe, Asia, and North America. Clinically proven as to be an exceptional antiviral, this mushroom has been the subject of much current medical interest.

A Greek physician called Diosorides described the Agarikon mushroom as "the elixir of long life" in 65 A.D. in his Materia Medica. The mushrooms themselves have been known to live for up to 75 years! Natives living in the Pacific Northwest also used to mushroom for a variety of medicinal purposes.

Many scientific studies have been conducted on the mushroom. Today, we know that Agarikon mushrooms:
• have anti-inflammatory and antibacterial properties
• have strong anti-viral activity
• alleviate the side effects of harsh treatments (like chemotherapy)
• strengthen the immune system
• provide respiratory system support

According to RenegadeHealth, the Agarikon mushroom is #3 in the list of Top 5 Medicinal Mushrooms. Additionally, the Institute for Tuberculosis Research at the University of Illinois conducted a study which proved that strains of the Agarikon mushroom will seek out and attack tuberculosis bacterium.

Abstract from MEDLINE PUBMED

In December 2010 the Ministry of Health and Social Welfare of the Republic of Croatia registered tablet preparations AGARIKON. 1 and MYKOPROTECT. 1, developed by Dr Myko San-Health From Mushrooms Co., as dietary supplements. This may be the first time for a European manufacturer to successfully register its own medicinal mushroom products in a European country. As a product with a very broad spectrum of action, officially described as a preparation for immunity strengthening and general health improvement, AGARIKON.1 is a result of 20 years of research and practice, and is based on the formulation that has achieved the best tumor growth inhibition rates-above 90% on tumor cell lines of mouse squamous cell carcinoma and fibrosarcoma. Since the usage of massive dosages of proprietary blended liquid mushroom extracts in patients with breast, colorectal, lung, and other cancers significantly improved their survival rates, alleviated side effects of standard oncological therapies, improved their quality of life, and resulted in life prolongation-the very idea is that scientifically verified medicinal mushroom products can be used as powerful biological weapons to fight human malignancies. If progressive modem medicine were redefined in a more effective and humane way, cancer mycotherapy should be a part of a broad concept of biological prevention and therapy of cancer. Also, with a very broad spectrum of action, generally formulated as "to strengthen immunity," MYKOPROTECT. 1 is intended as an important element in the prevention and fighting of serious viral infections, whether they are caused by well-known viruses (hepatitis, HIV, etc.) or newly emerging ones.
PMID:
 
22135883
 
[PubMed - indexed for MEDLINE]



Agarikon.1 is a result of long-term, comprehensive research. It works in the lab, in vitro (cell cultures) and in vivo (on animal models). What separates Myko San’s Agarikon.1 is that we also know it works in humans – we have conducted 3 human cohort studies during development.
In addition, we have analyzed the medical records of more than 20,000 users over a 20-year period. After a detailed follow up and statistical analysis, we refined our products, dosage, and regimen. Repeating this process several times, we have greatly improved the efficacy. We were less dependent on guesswork or blindly following traditional advice, and more on science and experimental data.
Agarikon.1 component strongly inhibits squamous cell carcinoma.
Effects of Agarikon.1 on squamous cell carcinoma in vitro.
Left is the control; on the right a 50% concentration of a single Agarikon.1 component demonstrating a direct cytotoxic effect (killing cancer cells).

Source: Rudjer Boskovic Institute
Myko San medicinal mushroom supplements increase survival in patients with lung cancer
The comparison of metastatic non-small cell lung carcinoma survival rates: patients receiving just standard oncological therapy (ST) had much lower survival than those who used ST together with Myko San products (MT). (single blind, randomized cohort study, N=20, stage IV NSCLC lung cancer)
I. Jakopovich, New Dietary Supplements from Medicinal Mushrooms: Dr Myko San–A Registration Report, International Journal of Medicinal Mushrooms, Vol 13 i3 p.307-313, 2011
Agarikon.1 medicinal mushrooms extract blend inhibits cancer (squamous cell carcinoma and fibrosarcoma) much better than its components.
Agarikon.1 exhibits stronger cytotoxic effects in vitro on squamous cell carcinoma (SCCVII, blue bars) and fibrosarcoma (FsaR, red bars) than any of its components, as a result of synergy of active compounds. Lower bars indicate a higher percentage of destroyed cancer cells (better effect).
Source: Rudjer Boskovic Institute

The majority of modern medicines originate in nature. Although some mushrooms have been used in therapies for thousands of years, we are still discovering new potential medicines hidden within them. For many years, I have sought and studied Agarikon, an unusual mushroom native to the old growth conifer forests of North America and Europe. A big wood conk -- a perennial polypore -- Agarikon survives for many years and emits spores through whitish pores from its underside each summer (see photo below). This beehive-shaped mushroom may be the longest living mushroom in the world, growing in the temperate conifer forests of Northern California, Oregon, Washington, and British Columbia. This species also survives, precariously, on old growth larch trees in the Slovenian Alps, near the borders of Italy and Austria. Agarikon has two commonly used scientific names: Laricifomes officinalis, preferred for those specimens found on larch trees (Larix species), andFomitopsis officinalis, which applies to those hosted by Douglas fir, spruce, and hemlock.
2012-09-06-DustyandAgarikon.jpg
Dusty Yao holding a 40 year-old Agarikon polypore mushroom.
Mycologists at Fungi Perfecti maintain a culture library of 44 strains of this rare mushroom that have been collected around the world over the past 20 years. Eleven of these strains were genetically sequenced and contributed the "genetic fingerprint" of Fomitopsis officinalis to GenBank at the National Center for Biotechnology Information in Maryland.
2012-09-06-ScottinFirTree.jpg
Scott Baker, a tree canopy expert, climbs a 700-year-old Douglas fir tree sporting a huge Agarikon 
The Greek physician Dioscorides described Agarikon as "elixirium ad longam vitam" ("the elixir of long life") in 65 A.D. in Materia Medica -- essentially the first known herbal medical manual that listed remedies for fighting diseases. Historically, Agarikon has also been known as the "quinine conk" for its strong bitter taste but should not be confused with true quinine, which is chemically different. In ancient Greece, Agarikon was recommended for treating respiratory illnesses, night sweats, and consumption -- later termed tuberculosis.
Working with the Institute for Tuberculosis Research (ITR) at the University of Illinois at Chicago, we submitted specimens for testing against tuberculosis bacteria. The institute's director, Dr. Scott Franzblau, and his graduate student Chang-Hwa Hwang identified two novel coumarins unique to Agarikon showing anti-tubercular activity (Hwang et al., 2012). These purified compounds are about one or two orders of magnitude away in terms of potency to be considered as drugs; however, their chemical structures may be altered to confer greater biological effects. This effort may transform them into a potential means to counter the epidemic of multidrug-resistant tuberculosis that is sweeping the planet.
Agarikon is not only a strong anti-inflammatory and antibacterial agent, its extracts have also demonstrated antiviral properties. In the wake of the Sept. 11 attack, our team submitted more than 500 samples of diverse mushroom extracts to the BioShield BioDefense program, administered cooperatively by the National Institutes of Health and the U.S. Army Medical Research Institute of Infectious Diseases. After many panels of tests, the species that stood out was Agarikon.
Of the 11 strains of Agarikon from North America that were tested, a few showed exceptionally strong activity against viruses including pox (cowpox), swine (H1N1) and bird (H5N1) flu, and herpes (HSV1, HSV2) viruses. In several sets of tests, dilutions of our natural ethanol extracts against flu viruses exceeded the potency of the positive drug control -- ribavirin -- against flu viruses by a factor of 10 or more. Most recently, a team of Russian researchers has confirmed the strong antiviral activity of Agarikon against H5N1 flu virus and found that Agarikon is comparatively non-toxic to human cells (Teplyakova et al., 2012).
Agarikon contains antiviral molecules new to science. Researchers for pharmaceutical companies may have missed its potent antiviral properties. Our analyses show that the mycelial cultures of this mushroom are most active but that the fruitbodies, the natural form of the mushroom, are not. The fact that Agarikon is active against both viruses and bacteria suggests that it can provide a natural bioshield against potential infection and disease transmission. As the medical values of Agarikon continue to be researched, the value of biodiversity -- or mycodiversity -- of this species can truly be appreciated.
Given these preliminary in vitro results, we need to further explore mushroom-based natural products. Many medicinal solutions may reside within the biological populations of our natural habitats. Viruses and bacteria are rapidly mutating, threatening to overwhelm our health care system. In his book The Viral Storm: The Dawn of the New Pandemic Age, Dr. Nathan Wolfe argues that we live in a time when the transmission of viruses is virtually unstoppable given international air travel and the co-mingling of genomes.

This PDF link is pretty detailed on the biochemistry.

PDF LUNG CANCER STUDY VERY GOOD RESULTS! READ THIS


References:
Hwang, C.H., B.U. Jaki, L.L. Klein, D.C. Lankin, J. McAlpine, J.G. Napolitano, S.G. Franzblau, S.H. Cho, P.E. Stamets, G.F. Pauli. 2012. "Biological and chemical evaluation of anti-TB coumarins from the polypore mushroom, Fomitopsis officinalis." Planta Medica 2012; 78 DOI: 10.1055/s-0032-1321157.
Stamets, P. 2001. "Novel anti-virals from mushrooms." Herbalgram 51: 24-27.
Stamets, P. 2005. "Antipox properties of Fomitopsis officinalis (Vill.:Fr.) Bondartsev et Singer (Agarikon) from the Pacific Northwest of North America." International Journal of Medicinal Mushrooms. 7 (3):495-506. DOI: 10.1615/IntJMedMushr.v7.i3.60
Stamets, P. 2008. "Antiviral and antibacterial activity from medicinal mushrooms." U.S. Patent Application # 12/284,646. Filed September 24, 2008.
Teplyakova, T.V, N.V. Purtseva, T.A. Kosogova, V.A. Khanin, V.A. Vlassenko. 2012. Antiviral activity of polyporoid mushrooms (higher Basidiomycetes) from Altal mountains from Russia. International Journal of Medicinal Mushrooms. 14 (1):37-45.
Wofle, Nathan. 2011. The Viral Storm: The Dawn of the New Pandemic Age. New York: Henry Holt and Company, 2011.


I just started Lucy on these 08/16/2015. Cancer Dx by biospy on 4/2011.
I ordered them from Swansonvitamins but they are also on Amazon.com
But I may get next from here http://1stchineseherbs.com/agarikon-laricifomes-officinalis-myriad-mycology-mushroom-powder-1-lb/# in a 1 pound bag cheaper.
Since her cancer is nasal cancer I am hoping that it hits it on cancer, inflammation, and infection control.



Lucy never did radiation or chemo, she only did the Tippner Protocol. The Tippner Cancer Protocol combines immunotherapy and molecular cancer therapy using off the shelf readily available inexpensive natural substances. Here is her list. She is past 4 years after diagnosis by biopsy

I buy most of the stuff from Swanson Vitamins. They are cheaper, in capsules for dosage changes, and carry almost everything I give to Lucy except for the Chinese Herbs Stasis Breaker prescription, and the Low Dose Naltrexone prescription. Here is a $5 off coupon link I found


July 30, 2015

Yun Nan Bai Yao supplies Yunnan


For some reason all the vendors on Amazon raised the prices on Yun Nan Bai Yao ALOT!
I found this place in CA and it's like half price. For now anyway...

Yun Nan Bai Yao Active Herb


It's way cheap from Hong Kong.  I received it in 2 weeks
http://yunnanbaiyaostore.com/buy_yunnan_baiyao_capsules(Jiaonang)10boxes.html


July 10, 2015

Chemistry and immunomodulatory activity of frankincense oil





 2003 Mar-Apr;58(3-4):230-8.

Chemistry and immunomodulatory activity of frankincense oil.

Abstract

The yield of steam distillation of frankincense essential oil (3%); and its physicochemical constants were determined. Capillary GC/MS technique was used for the analysis of the oil. Several oil components were identified based upon comparison of their mass spectral data with those of reference compounds published in literature or stored in a computer library. The oil was found to contain monoterpenes (13.1%), sesquiterpenes (1%), and diterpenes (42.5%). The major components of the oil were duva-3,9,13-trien-1,5alpha-diol-1-acetate (21.4%), octyl acetate (13.4%), o-methyl anisole (7.6%), naphthalene decahydro-1,1,4a-trimethyl-6-methylene-5-(3-methyl-2-pentenyl) (5.7%), thunbergol (4.1%), phenanthrene-7-ethenyl-1,2,3,4,4a,5,6,7,8,9,10,10a-dodecahydro-1,1,4a,7-tetramethyl (4.1%), alpha-pinene (3.1%), sclarene (2.9%), 9-cis-retinal (2.8%), octyl formate (1.4%), verticiol (1.2%) decyl acetate (1.2%), n-octanol (1.1%). The chemical profile of the oil is considered as a chemotaxonomical marker that confirmed the botanical and geographical source of the resin. Biologically, the oil exhibited a strong immunostimulant activity (90% lymphocyte transformation) when assessed by a lymphocyte proliferation assay.



Composition and potential anticancer activities of essential oils obtained from myrrh and frankincense
Chen Y, Zhou C, Ge Z, Liu Y, Liu Y, Feng W, Li S, Chen G, Wei T
Oncology Letters, 2013

ABSTRACT:
CITATION:
The present study aimed to investigate the composition and potential anticancer activities of essential oils obtained from two species, myrrh and frankincense, by hydrodistillation. Using gas chromatography-mass spectrometry (GC-MS), 76 and 99 components were identified in the myrrh and frankincense essential oils, respectively, with the most abundant components, 2-Cyclohexen-1-one, 4-ethynyl-4-hydroxy-3,5,5-trimethyl- and n-Octylacetate, accounting for 12.01 and 34.66%, respectively. The effects of the two essential oils, independently and as a mixture, on five tumor cell lines, MCF-7, HS-1, HepG2, HeLa and A549, were investigated using the MTT assay. The results indicated that the MCF-7 and HS-1 cell lines showed increased sensitivity to the myrrh and frankincense essential oils compared with the remaining cell lines. In addition, the anticancer effects of myrrh were markedly increased compared with those of frankincense, however, no significant synergistic effects were identified. The flow cytometry results indicated that apoptosis may be a major contributor to the biological efficacy of MCF-7 cells.
Chen Y, Zhou C, Ge Z, et al. Composition and potential anticancer activities of essential oils obtained from myrrh and frankincense. Oncol Lett. 2013;6(4):1140-1146.

 2009 Mar 18;9:6. doi: 10.1186/1472-6882-9-6.

Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity.

Abstract

BACKGROUND:

Originating from Africa, India, and the Middle East, frankincense oil has been important both socially and economically as an ingredient in incense and perfumes for thousands of years. Frankincense oil is prepared from aromatic hardened gum resins obtained by tapping Boswellia trees. One of the main components of frankincense oil is boswellic acid, a component known to have anti-neoplastic properties. The goal of this study was to evaluate frankincense oil for its anti-tumor activity and signaling pathways in bladder cancer cells.

METHODS:

Frankincense oil-induced cell viability was investigated in human bladder cancer J82 cells and immortalized normal bladder urothelial UROtsa cells. Temporal regulation of frankincense oil-activated gene expression in bladder cancer cells was identified by microarray and bioinformatics analysis.

RESULTS:

Within a range of concentration, frankincense oil suppressed cell viability in bladder transitional carcinoma J82 cells but not in UROtsa cells. Comprehensive gene expression analysis confirmed that frankincense oil activates genes that are responsible for cell cycle arrest, cell growth suppression, and apoptosis in J82 cells. However, frankincense oil-induced cell death in J82 cells did not result in DNA fragmentation, a hallmark of apoptosis.

CONCLUSION:

Frankincense oil appears to distinguish cancerous from normal bladder cells and suppress cancer cell viability. Microarray and bioinformatics analysis proposed multiple pathways that can be activated by frankincense oil to induce bladder cancer cell death. Frankincense oil might represent an alternative intravesical agent for bladder cancer treatment.


 2011 Dec 15;11:129. doi: 10.1186/1472-6882-11-129.

Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells.


Abstract

BACKGROUND:

Gum resins obtained from trees of the Burseraceae family (Boswellia sp.) are important ingredients in incense and perfumes. Extracts prepared from Boswellia sp. gum resins have been shown to possess anti-inflammatory and anti-neoplastic effects. Essential oil prepared by distillation of the gum resin traditionally used for aromatic therapy has also been shown to have tumor cell-specific anti-proliferative and pro-apoptotic activities. The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells.

METHODS:

Boswellia sacra essential oil was prepared from Omani Hougari grade resins through hydrodistillation at 78 or 100 °C for 12 hours. Chemical compositions were identified by gas chromatography-mass spectrometry; and total boswellic acids contents were quantified by high-performance liquid chromatography. Boswellia sacra essential oil-mediated cell viability and death were studied in established human breast cancer cell lines (T47D, MCF7, MDA-MB-231) and an immortalized normal human breast cell line (MCF10-2A). Apoptosis was assayed by genomic DNA fragmentation. Anti-invasive and anti-multicellular tumor properties were evaluated by cellular network and spheroid formation models, respectively. Western blot analysis was performed to study Boswellia sacra essential oil-regulated proteins involved in apoptosis, signaling pathways, and cell cycle regulation.

RESULTS:

More abundant high molecular weight compounds, including boswellic acids, were present in Boswellia sacra essential oil prepared at 100 °C hydrodistillation. All three human breast cancer cell lines were sensitive to essential oil treatment with reduced cell viability and elevated cell death, whereas the immortalized normal human breast cell line was more resistant to essential oil treatment. Boswellia sacra essential oil hydrodistilled at 100 °C was more potent than the essential oil prepared at 78 °C in inducing cancer cell death, preventing the cellular network formation (MDA-MB-231) cells on Matrigel, causing the breakdown of multicellular tumor spheroids (T47D cells), and regulating molecules involved in apoptosis, signal transduction, and cell cycle progression.

CONCLUSIONS:

Similar to our previous observations in human bladder cancer cells, Boswellia sacra essential oil induces breast cancer cell-specific cytotoxicity. Suppression of cellular network formation and disruption of spheroid development of breast cancer cells by Boswellia sacra essential oil suggest that the essential oil may be effective for advanced breast cancer. Consistently, the essential oil represses signaling pathways and cell cycle regulators that have been proposed as therapeutic targets for breast cancer.



I am still researching this. Lucy is taking Boswellia this is already part of the COX-2 Combo pill.


Lucy never did radiation or chemo, she only did the Tippner Protocol. The Tippner Cancer Protocol combines immunotherapy and molecular cancer therapy using off the shelf readily available inexpensive natural substances. Here is her list. She is past 4 years after diagnosis by biopsy

I buy most of the stuff from Swanson Vitamins. They are cheaper, in capsules for dosage changes, and carry almost everything I give to Lucy except for the Chinese Herbs Stasis Breaker prescription, and the Low Dose Naltrexone prescription. Here is a $5 off coupon link I found